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Efficient Ball Mill Procedure In The Green Asymmetric

The organocatalytic activity of S-proline-based dipeptides 1ac has been evaluated in the asymmetric aldol reaction between representative ketones with various aromatic aldehydes under solvent-free conditions in a ball mill.In particular the methyl ester of S-proline-S-tryptophan SS-1c proved to be an efficient organocatalyst and the aldol reaction proceeded with good chemical

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